MORE: How Science Is Messing with Your Morning Coffee If your answer is Literally as soon as I drag myself out of bed or else I will die (or something to that effect), you’re wrong. A few years back, research showed that drinking coffee right when you wake up can actually blunt the effects of caffeine and make you even more dependent on the drug. This new video, from the dry-erase aficionados over at ASAPScience, explains why.